Effectiveness of HCG injection for weight loss

Human chorionic gonadotropin (HCG), produced by the placenta (trophoblast) and excreted in urine of pregnant women, is a water-soluble dimeric glycoprotein hormone composed of the alpha subunit (containing 92 amino acids) and beta subunits (containing 145 amino acids). Other members in the family of glycoprotein hormones include follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), and luteinizing hormone (LH). The alpha subunits of these pituitary hormones have the same peptide structure, while their beta subunits are slightly different in amino acid sequence and length. HCG is found only in pregnant women with the peak level during the first pregnancy trimester. This hormone is generally not present in non-pregnant females or in males. Human chorionic gonadotropin functions to stimulate the gonads development in the fetus. Qualitative or quantitative analysis of chorionic gonadotropin is used in diagnosing pregnancy, choriocarcinoma or ectopic pregnancy.

Human chorionic gonadotropin has been found useful in the treatment of several human disorders. Because the biological property of human chorionic gonadotropin is very close to that of luteinizing hormone. The peptide structures of beta subunits of these two hormones are tightly related to each other and they bind to the same receptor and the same biological reaction is induced. Human chorionic gonadotropin is much more easily available than luteinizing hormone. In fact HCG has been proven to be more effective than LH in several cases of infertility treatment. HCG products are also used to treat threatened abortion, delayed adolescence, oligospermia, hypogonadotropic hypogonadism and prepubertal cryptorchidism (non anatomical obstruction resulted). In addition, human chorionic gonadotropin has been found effective in treatment of women with luteal phase defects and disorders of the menstrual cycle.

HCG injections have been claimed to be effective in weight loss by aiding in localized reduction, affecting mood and suppressing hunger. This obesity therapy (injections of HGH and dietary modification) was introduced by Simeons in 19541 but its effectiveness has been disputed for a long time. Simeons developed the weight loss therapy based on his experience of treating young boys suffering from dystrophia adipositogenitalis (the Frohlich syndrome) using human chorionic gonadotropin. It is claimed that obese patients treated with the Simeons therapy will have a rapid weight loss without feeling weak and hungry. Despite the ambiguous evidence of its effectiveness, low-dose injectable HCG combined with a weight loss diet remains a popular method for weight control and obesity treatment. However, a recent test shows the HCG therapy doesn’t promote weight loss and HCG diet has no advantage over the calorie restriction method in weight reduction.

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  1. this is the craziest thing ive ever heard. no quick fix poeple.

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